Get 24-hour relief from frequent heartburn with Nexium 24HR ClearMinis. It provides the same complete protection (3) from frequent heartburn in a potent little pill. Nexium 24HR ClearMinis work by blocking acid directly at the source, giving you 24 hours of protection (4) from frequent heartburn. Just one pill a day provides all-day, all-night protection (4) from frequent heartburn. Nexium 24HR is the #1 Selling OTC frequent heartburn brand (2). It's possible while taking Nexium 24HR. Use as directed for 14 days to treat frequent heartburn. Do not take for more than 14 days or more often than every 4 months unless directed by a doctor. Not for immediate relief. (1) Among PCPs and Pharmacists who use a branded OTC PPI (2) Among OTC PPI brands. Based on IRI sales data 52 weeks ending 09/04/2016. (3) It's possible while taking Nexium 24HR. Use as directed for 14 days to treat frequent heartburn. Do not take for more than 14 days or more often than every 4 months unless directed by a doctor. Not for immediate relief. (4) Use as directed for 14 days to treat frequent heartburn. Nexium 24HR may take 1-4 days for full effect. HSA/FSA EligibleRestrictions apply; contact your insurance provider about plan allowances and requirements.