Monistat 7 Day Vaginal Antifungal Treatment with Disposable ApplicatorVaginal itching And discomfort for the first time; lower abdominal, back or shoulder pain, fever, chills, nausea, vomiting, or foul-smelling vaginal discharge. You may have a more serious condition; vaginal yeast infections often (such as once a month or 3 in 6 months). You could be pregnant or have a series underlying medical cause for your symptoms, including diabetes or a weakened immune system; been exposed to the human immunodeficiency virus (hiv) that causes aids.