Powerful Migraine Relief Medicine Excedrin Migraine Caplets for Migraine Headache Relief work fast to combat migraine headache pain, making Excedrin Migraine the #1 neurologist recommended OTC treatment for migraines. Available in convenient caplet form, this powerful migraine medicine delivers a specialized triple action formula containing two pain fighters and an amplifier. These Excedrin caplets combine aspirin and acetaminophen with caffeine to provide migraine relief, including migraine headache pain, sensitivity to light and sound, and nausea. For some, this migraine headache relief medicine starts relieving migraine pain in 30 minutes. Among OTC medicine for migraines IQVIA, Inc., 2018.